Bacterial Artificial Chromosome Transgenesis Through Pronuclear Injection of...
SummaryIn the mouse, conventional transgenes often produced unpredictable results mainly because they were too small to recapitulate a natural gene context. Bacterial artificial chromosomes (BACs) are...
View ArticleThe histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in...
AbstractBackgroundHistone methylation is thought to be central to the epigenetic mechanisms that maintain and confine cellular identity in multi-cellular organisms. To examine epigenetic roles in...
View ArticleThe mammalian gene function resource: the international knockout mouse...
AbstractIn 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide...
View Article
More Pages to Explore .....
